Short answer, yes it will impact the way he learns the rules.
Long answer is that the basics of the game are the same, but detailed rules about vehicles, and close combat work will be different. To be honest if he doesn't want to spend 60 on the 5th ed book, he has the option of going on ebay and picking up the Assault on Black Reach Rule book, which is usually 20 bucks.
Edit: As Capn said, we're in a new edition year so be ready for only a big rule book rulebook update sometime this year.